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Objective:To study the clinical features and genotypes of neonatal Glanzmann thrombasthenia(NGT).Methods:A male neonate with NGT admitted to the Department of Neonatology of our hospital was retrospectively reviewed. CNKI, Wangfang database, VIP, the Chinese Medical Journal Full Text database, PubMed and Embase database were searched using key words '(neonate OR newborn) AND (Glanzmann thrombasthenia)' both in English and Chinese. The clinical features and genotypes of NGT were summarized and analyzed.Results:A male full-term neonate was admitted to our hospital for mass on the forehead and ecchymosis and petechiae on the body within half an hour after birth. He gradually developed subgaleal hemorrhage and severe anemia. Platelet count, mean platelet volume and coagulation functions were normal. The platelet aggregation test indicated decreased platelet aggregation rate induced by arachidonic acid and adenosine diphosphate. Genetic testing revealed two heterozygous mutations in the patient's ITGA2B gene: NM_000419.4: c.886G>A(p.Gly296Arg) and NM_000419.4: c.2855dup(p.Phe953Valfs*83). A total of 42 literature involving 44 patients (our case included) with NGT were retrieved. 33 cases (75.0%) of NGT showed ecchymosis or petechiae on the first day after birth. For 13 cases with detailed information, 5 cases with severe anemia were given erythrocyte and plasma transfusion and platelet transfusion was given in 1 case. 4 cases had homozygous variants and 4 cases showed compound heterozygous variants. 10 cases had follow-up records, including 2 cases without any bleeding and 8 cases with varying degrees of bleeding during follow-up. No deaths were reported.Conclusions:Neonates with ecchymosis and petechiae in the early postnatal period should be suspected of NGT. Blood transfusion is preferred when the indication for transfusion is met.
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Objective:To describe the status and influencing factors of the empowerment of caregivers after gastrointestinal tumor.Methods:From March 2019 to October 2019, using convenience sampling method, 124 pairs of gastrointestinal tumor patients and caregivers who were hospitalized in the general surgery and anorectal surgery of the department of Shandong Tai′an City Central Hospital and the Second Affiliated Hospital of Shandong First Medical University were selected as the subjects. A general information questionnaire, Main Caregivers′Empowerment Measurement were used as research tools. To investigate the empowerment ability of caregivers of patients with gastrointestinal tumors after operation.Results:The total caregiver′s empowerment score was 168.81 ± 19.49. The scores of each dimension ranged from high to low: relationship with caregivers (3.83 ± 0.43), expectation of care outcomes (3.80 ± 0.43), awareness of caregiving roles (3.70 ± 0.51), caregivers′ subjectivity (3.37 ± 0.60), caregiving beliefs (3.34 ± 0.67), caregiving knowledge and skills (3.27 ± 0.73), personal resources (2.94 ± 0.65), goodwill caregiving (2.85 ± 0.65) , the scruples around (2.75 ± 0.88). Multiple linear regression results showed that, patient gender, whether the disease is first attack, whether the patient is aware of the disease, the caregiver marriage, and the caregiver working status were the influencing factors of the caregiver′s empowerment ability after gastrointestinal tumor operation ( t values were -8.15-8.72, R2=0.62, all P<0.05). Conclusions:There is room for further improvement in the empowerment of caregivers after gastrointestinal tumor surgery, especially in personal resources, goodwill care and scruples around. The results suggest that medical staff should guide caregivers to emancipate their minds, enhance the breadth of empowerment, and promote self care and fast rehabilitation of patients.
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Objective:To analyze the status and influencing factors of long-term care demand of the community elderly in Taian and in order to provide a theoretical basis for the government to formulate policies to meet the needs of the elderly.Methods:A self-designed questionnaire was used to investigate 294 elderly aged 60 years in three areas in Tai'an using Convenient sampling.Results:The total average score of long-term care demand was (2.67±0.46). The top three demand are economic, chronic disease rehabilitation, and dignity demand. Multiple linear regression showed that age, living conditions, place of residence, and chronic disease were the influencing factors of long-term care needs ( P<0.05). Conclusions:The long-term care needs of the elderly in Tai'an community were at a medium level, Age, living conditions, place of residence and chronic diseases have different effects on long-term care demand. It is suggested that the government and medical staff should pay more attention to the economic, rehabilitation and dignity needs of the elderly in the community, and formulate and implement relevant policies to meet the needs of the elderly in order to improve the quality of life and happiness of the elderly.
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Objective:To investigate the present situation of delayed medical care for patients with senile cataract and analyze the influencing factors.Methods:Totally 636 senile cataract patients in Baoji Eye Hospital from January to September, 2017 were recruited. They were investigated using the current status of medical delay questionnaire.Results:The detection rate of delayed medical care for elderly patients with cataract was 36.95%(235/650). Logistic analysis demonstrated that significant influencing factors for patient delay included age, place of residence, educational level, hypertension, diabetes, medical insurance, distance and time for place of residence to the nearest medical unit for elderly cataract patients ( P<0.05) . Conclusion:There are widespread medical delays in elderly cataract patients in Baoji City. We should strengthen health education for elderly cataract patients, provide social support, and develop targeted measures to promote timely medical treatment, reduce blindness and increase quality of life.
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Objective@#To investigate the present situation of spiritual health and empathy of undergraduate nursing students, and explore the correlation between them.@*Methods@#Convenient sampling was used and 498 senior nursing students were recruited from 2 universities in Shandong Province. They were investigated using the general questionnaire, the Spiritual Health Scale Short Form and Chinese version of the Interpersonal Reactivity Index.@*Results@#The total score of spiritual health was (92.87±12.28), the 5 dimensions of the item score from high to low were connection to others (4.46±0.62), meaning derived from living (4.15±0.69), self-understanding (4.03±0.72), transcendence (3.95±0.74) and religious attachment (2.60±1.08). The total score of Interpersonal Reactivity Index was (57.50±8.35), the 5 dimensions of the item score from high to low were perspective taking (2.78±0.61), empathy concern (2.72±0.56), fantasy (2.61±0.57), personal distress (2.32±0.78). Nursing students’ spiritual health score and empathy was positively correlated (r=0.334, P<0.01). Regression analysis, single-child (B=0.202, P<0.05), exercise habit (B=0.363, P<0.01), religious belief (B=0.381, P<0.01), academic performance (B=0.205, P<0.05), nursing career in the future (B=0.285, P<0.01) were the influencing factors of nursing students′ spiritual health.@*Conclusions@#Spiritual health is closely related to empathy; the higher the level of spiritual health, the higher the empathy ability. It suggests that nursing educators can improve nursing students′ empathy by improving the spiritual health of nursing students.
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Objective@#To investigate the impacts of sports game curriculum on the physical development of preschool children aged 3 to 5 years, so as to provide a reference for sports education and intervention among preschool children.@*Methods@#Totally 176 preschool children aged 3 to 5 years in the large, medium and small class of a kindergarten in Changzhou were selected by means of cluster random sampling, and they were randomly divided into observation group (n=85) and control group(n=91). The control group did not receive special intervention, while the observation group received sports game curriculum, the intervention time was 1 year. The body shape and physical fitness indicators were tested and compared before and after intervention.@*Results@#In terms of body shape, the increase in height of the observation group was (6.57±0.41)cm, which was significantly higher than (5.77±0.36)cm of the control group(t=13.78, P<0.01); There was no significant difference in weight gain between the observation group and the control group (2.53±0.35)kg vs (2.61±0.43)kg(t=1.35, P>0.05). The physical fitness indicators, including standing long jump, continuous jumping of the feet, sit-and-reach, tennis throwing, single foot balance and 10 m×2 shuttle run effects were (95.93±4.02)cm, (6.72±0.35)s, (11.65±1.33)cm, (6.21±1.50)m, (45.26±8.74)s,(6.91±0.13)s in the observation group, significantly better than (82.71±3.59)cm, (7.52±0.41)s, (10.06±1.32)cm, (5.34±1.21)m, (36.14±6.72)s, (7.36±0.17)s in the control group(t=23.04, 13.88, 7.96, 4.25, 7.79, 19.63, P<0.05).@*Conclusion@#The sports game curriculum has no significant effect on the weight of preschool children aged 3 to 5, but it can promote the height growth of children and helps to improve physical fitness.
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Objective To explore the diagnostic value of contrast-enhanced ultrasound combined with tumor markers in benign and malignant ovarian tumors.Methods The clinical data of 100 patients with ovarian tumors treated in our hospital from May 2016 to May 2017 were analyzed retrospectively.The parameters of contrast-enhanced ultrasonography (CEUS) for benign and malignant ovarian tumors were analyzed.The levels of tumor markers were measured and the ultrasound imaging was analyzed.Analysis of the detection rate of benign and malignant ovarian tumors by contrast-enhanced ultrasound alone or in combination with tumor markers.Results Compared with benign ovarian tumors,ovarian malignant tumors have the characteristics of uneven enhancement,early onset and peak time of contrast enhancement,and higher rate of enhancement (P ＜ 0.05);compared with benign ovarian tumors,serum CA125 and CA199 levels in patients with ovarian malignant tumors were higher,with significant difference (P ＜ 0.05).The detection rates of contrast-enhanced ultrasound combined with tumor markers were higher than those of ultrasound or tumor markers alone,and were in accordance with pathological criteria.Conclusions The application of combined contrast-enhanced ultrasound and tumor markers in the diagnosis of ovarian benign and malignant tumors has a high detection rate,can significantly improve the accuracy of clinical detection,and provide a strong basis for treatment.
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Objective To investigate the present situation of spiritual health and empathy of undergraduate nursing students, and explore the correlation between them. Methods Convenient sampling was used and 498 senior nursing students were recruited from 2 universities in Shandong Province. They were investigated using the general questionnaire, the Spiritual Health Scale Short Form and Chinese version of the Interpersonal Reactivity Index. Results The total score of spiritual health was (92.87±12.28), the 5 dimensions of the item score from high to low were connection to others (4.46± 0.62), meaning derived from living (4.15 ± 0.69), self-understanding (4.03 ± 0.72), transcendence (3.95 ± 0.74) and religious attachment (2.60±1.08). The total score of Interpersonal Reactivity Index was (57.50± 8.35), the 5 dimensions of the item score from high to low were perspective taking (2.78±0.61), empathy concern (2.72±0.56), fantasy (2.61±0.57), personal distress (2.32±0.78). Nursing students’spiritual health score and empathy was positively correlated (r=0.334,P<0.01). Regression analysis, single-child (B=0.202, P<0.05), exercise habit (B=0.363, P<0.01), religious belief (B=0.381, P<0.01), academic performance (B=0.205, P<0.05), nursing career in the future (B=0.285, P<0.01) were the influencing factors of nursing students′ spiritual health. Conclusions Spiritual health is closely related to empathy; the higher the level of spiritual health, the higher the empathy ability. It suggests that nursing educators can improve nursing students′ empathy by improving the spiritual health of nursing students.
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Follicular lymphoma (FL) is a kind of indolent non-Hodgkin lymphoma (iNHL), which origins from follicle germinal center. Multiple researches reported the latest development about treatment of FL in the 58th American Society of Hematology (ASH) Annual Meeting. The outcomes of clinical trials in which GAl01 combined with chemotherapy and bendamustine in combination with 90Y-ibritumomab tiuxetan for the advanced stage FL were exciting. Relapsed/refractory FL patients who receive tandem autologous followed by nonmyeloablative allogeneic transplantation could acquire preferable remissions. With the emerging of novel drugs including inhibitor of bcl-2 or PI3K and antibody drug conjugate, more and more improvements of efficacy and remission were made in the treatment of relapsed/refractory FL therapy and remission.
